Karthik and Swetha’s marital bliss is shattered when they are reminded of their past lovers. They then decide to separate but must face their respective families.

A rescue mission is assembled in Thailand where a group of young boys and their soccer coach are trapped in a system of underground caves that are flooding.

Dr. Rajkumar, Kanchana, Jayamala and Padmapriya are played the main lead roles along with Vajramuni, Thoogudeepa Srinivas, Balakrishna, Sampath, Bhadrachalam, Chandrashekhar, Shivaprakash, Udayashankar, Prabhakar and many others are seen in supporting roles in this movie.

Reading the plot synopsis of Guru Uchchathula Irukkaru, you might think that this could be an entertaining film, but the sad truth is that this is as engaging as watching paint dry

Fourteen-year-old Kartik is passionate about cricket and considers cricketer Dhoni as his idol. But his father does not approve of it and wants him to pursue an MBA degree instead.

The movie revolves around Chandru (Karthik) and his lover Niveditha (Malavika) in the backdrop of Ooty. Niveditha’s father Mahadevan (Manivannan) is against love marriages and he finds out that his daughter Niveditha is in love with someone. Mahadevan asks for the details of Niveditha’s lover. But Niveditha as per Chandru’s plan, hands over Azhagesh’s (Vivek) (who happens to be Chandru’s friend), photo to Mahadevan and informs him as her lover. Mahadevan sends some goons to attack Azhagesh and the proceedings happen comically.
Meanwhile, Chandru and Niveditha keeps planning on how to make Mahadevan nod for their wedding. One day, Mahadevan’s car gets repaired on the way. Chandru along with his family also comes on the same way. Seeing Mahadevan helpless on the road, Chandru picks him up and drops him at home thereby getting into good books of Mahadevan. Slowly, Mahadevan and Chandru become good family friends. But still, Chandru and Niveditha do not reveal their love to their parents and are happy that both families are in good terms now.

Vasudev Shastri (Utkarsh Sharma) is a topper yet charming man who comes into IIT where the second ranker, Nandini (Ishitha Chauhan), decides to make his life hell. But Vasu is smart and in love with her to be outmaneuver. Besides being the friendly ‘genius’ around campus, he has also got a part-time job working with RAW (Research and Analysis Wing) where his hacking talents are occupied.Vasu was orphaned when his parents were killed in communal riots. He was found by a priest who raised him in a temple complex in Mathura. The life-positive Vasu is the one we see in flashback. In the present, Vasu dresses in all-black, uses a walking stick and suffers from acute tinnitus. This troubled, damaged Vasu is the one who survived multiple bullet wounds during a high-level mission. Special agent Vasu heads a division of RAW called TOCSI, which was tracking public enemy number one, simply referred to as MRS (Nawazuddin Siddiqui). MRS had the ambition of insulting Jaishankar Prasad(Mithun Chakraborty) and thus he wanted Vasu to slap him in public. However at the end, MRS fails in his Vrindavan temple blast and finally Vasu kills MRS by drowning him in River.

Sridhar (Ajith Kumar) is from a middle-class family headed by his father (K. Vishwanath). Shiva (Raghuvaran) is Sridhar’s elder brother and the breadwinner for the family consisting of his wife Shantha (Sithara) and sister (Preitha Raghav). Sridhar, upon completion of his graduation, aspires to become a music director and tries hard to secure a chance in movies, but all his efforts go in vain. Sridhar’s search for a chance continues for 8 years. Despite that, his family members support him very well and encourage him whenever he feels dejected.

The story takes place in Panimalai, a hill city, during a spring season. The film begins with RJ Balaji coming to Panimalai to be a guest of a live radio show. In the middle of the show, he starts coughing severely and suddenly loses his voice. He is diagnosed with a new type of virus called the mute flu that causes sudden muteness and sometimes even death.
Aravindh (Dulquer Salman) is a sales representative working with a glue company. His dream is to become a radio jockey, and he even attends interviews with a FM station. As the mute flu spreads across the city, the state government sends Health Minister Sundaralingam (Pandiarajan) to Panimalai to take care of the situation. The people are asked to undergo a medical checkup to check whether they are affected by the virus or not. Aravindh goes to the hospital and meets Anjana (Nazriya Nazim), a junior doctor, who believes that talking is the only cause of all the problems in the world and if people keep things to themselves things will be very fine. Anjana is in a relationship with Vinodh (Abhinav), a possessive guy who always commands her on what she should do and what she should wear. Anjana lives with her father and stepmother Vidhya (Madhoo). Since Anjana lost her mother at a young age, she is reluctant to accept Vidhya as her mother, though she is a sweet and caring woman, and always maintains a distance from her. Vidhya is an aspiring writer who is trying to get her husband’s (Abhishek Shankar) attention and support to write her third book. Her husband finds no time to talk to her as he is too busy with his work.

Dhill is the story about Kanagavel (Vikram), whose only dream is to become a police officer. He succeeds in passing the exams and wins a girlfriend Asha (Laila). One night after having dinner at a restaurant near the beach, Kanagavel goes to pay the bill, leaving Asha behind. At that moment a corrupt police officer Shankar (Ashish Vidyarthi) drinks and behaves indecently to Asha. He then attempts to assault her but is severely beaten up by Kanagavel, and he receives a scar on his face. Shankar, angered by this, seeks revenge against Kanagavel. Kanagavel kills Shankar and his goons.

Appu and Raja are twin brothers who were separated soon after their birth. Years later Appu, a dwarf, has become a circus clown and is loved by everyone while Raja is a car mechanic. When Appu’s love is rejected as he is a dwarf he tries to commit suicide. His mother comforts him and reveals to him that while she was pregnant with her twins their father Sethupathy was killed by four criminals Francis, Dharmaraj, Nallasivam and Satyamoorthy and also poisoned her which is the reason he turned a dwarf. Appu now decides to take revenge against the criminals but his lost twin brother Raja is framed for his crimes by mistake.

Bhaskar (Arvind Swamy) is a business tycoon and single parent. His father Rangasamy (Nassar) is a retired businessman, and Bhaskar has taken over his businesses. Bhaskar deals with all the situations in his business with rowdyism and has a crude and crass personality. This behavior earns him the name ‘Rascal’. He is a widower and has a son Aakash (Master Raghavan). Aakash and Shivani (Baby Nainika) study in the same school. Shivani’s mother Anu (Amala Paul) is also a single parent. She meets Bhaskar at the school. Shivani admires Bhaskar for his authoritative stance and treats him like a father figure.