Gunasingam, a family-loving farmer who hails from a small town, tries his best to keep his big family united despite him being misunderstood by many.

The movie begins with Jeeva (Ajith Kumar), a driving instructor, leading a happy life with his mother (Sujatha). He also fell in love with Swapna (Pooja Umashankar) after several mishaps. Sujatha hides the Jeeva truth that his father (Nizhalgal Ravi), was murdered by a dada named Manthiram (Babu Antony). The mother, much against the boy’s wish, packs off Jeeva’s twin brother, Guru (also Ajith Kumar) with a family who offer to adopt him, who had been witness to the murderer from a close quarter, to a distant town. He escapes from the family and goes to Tuticorin and grows to become a gangster there.
When Jeeva visits Tuticorin, he comes across his elder brother, Guru a.k.a. Thala. Seizing the opportunity, the elder brother kidnaps the younger one and decides to go as the driving instructor to Chennai. Initially, he plans to take revenge on his mother for packing him off from their house at a very young age. He hurts her at every step and even plans to sell off all their property.

Aaditya, who has a unique syndrome, falls in love with Abhinaya and marries her. While on their honeymoon in Manali, their life takes a turn. Stuck in the coldest place on earth, will they fight to survive?

The film opens two years after the events of the first film, with Anitha Constructions Civil Engineer, Raghuvaran (Dhanush) winning the Civil Engineer of the Year 2016 Award and is an executive member of his company now, along with a parking spot. His wife, Dr. Shalini (Amala Paul) becomes an authoritative, nagging wife, who controls him. She has resigned her job to take care of the household, after marriage. Raghuvaran is also dismissive about his wife getting another job. Raghuvaran efficiently completes construction projects assigned to him, with the help of about 200 unemployed young Civil, Mechanical and Electrical engineers, who are his friends. Vasundhara (Kajol), a chairman of a big construction company in South India, Vasundhara Constructions, witness the announcement of Raghuvaran’s victory at the Engineer of the Year 2016 Awards and finds out about him. She makes Raghuvaran a job offer, but he humbly refuses, having been interested in creating his own construction company, VIP Constructions.

The film, however, follows familiar pattern of Spanish original, wherein a corpse mysteriously disappears from the city morgue. This leads to summoning of police officer to investigate the case of missing body. As usual needle of suspicion falls on woman’s husband. While Spanish film is noir genre cinema, Ramesh’s Game with its taut and gripping screenplay, is aptly tailored to suit the Indian audience’s palate. How, no-nonsense, smart cop Sharath Chandra unravels the truth; whether high profile lady Maya, has been murdered, is it a case of catalepsy, or case of drunken driving, hit and run, behind it, forms the fulcrum of eerie and edgy Game set in specially constructed forensic lab.

Two dons, Cheliyan and David are enemies. Cheliyan kills David’s brother so David swears to avenge his brother’s death and waits for the right opportunity. Shiva is a youth from Kumbakonam who unites lovers and his family supports him. This brings him several troubles, one of which from David when Shiva stops David’s marriage with a girl who refused to marry him. David wants to know who stopped his marriage and leaves the place without a word after seeing him. This worries his father, Ratnam as he fears that David might harm his son. Shiva hallucinates a woman who he calls Mala, who asks him ‘Why did you do like this?’ and he replies that he will correct everything. He is having a trouble for a reason and his family consoles him. Shiva’s sister is getting married and Shiva ensures that no trouble comes in the marriage. However, on the day before marriage, Shiva had to face a critical situation through David who threatens to stop his sister’s marriage like how Shiva stopped his marriage. Shiva begs David and tells him that he is ready to do anything for him in return of letting his sister’s marriage happen without any problem. David demands him to abduct a woman from Madurai, who is the daughter of Minister Manivasagam, an influential politician Madurai. Shiva agrees and leaves for Madurai missing his sister’s wedding.

A voice-over by RD (Anil Kapoor) introduces the four main characters: Ranvir Singh “Ronny” (Saif Ali Khan) who runs a successful business he inherited from his father. His younger brother Rajiv Singh (Akshaye Khanna) who mooches off of Ronny and is an alcoholic. Ronny is dating an upcoming model Sonia (Bipasha Basu), while his personal assistant Sophia (Katrina Kaif) appears to be secretly in love with him. Ronny is also involved in an intense competition with a rival horse-owner Kabir (Dalip Tahil). The film opens with a murder plot involving a car accident which Ronny narrowly survives. When Ronny loses money in a race because his jockey had been bribed by Kabir, Ronny plants a bomb in the jockey’s car and kills him, showing Ronny to be a ruthless businessman. Later, Ronny also destroys Kabir when the latter offers him money to buy his business, which is in debt.

Prabhu an average suburban man for whom his family is everything. His life is turned upside down when his daughter Satya is possessed by the ghost of a little boy.

Ganesh clashes with a trio of criminal brothers when he tips off the police about them. When they try to seek revenge, they realize he has a score to settle with them too.

Aadhavan, a professional sharpshooter, gets a contract to kill Subramaniam, a prominent judge. He enters his house as a servant and wins the heart of his family members while plotting his death.

Rahul embarks on a journey to a small town in Tamil Nadu to fulfill the last wish of his grandfather: to have his ashes immersed in the Holy water of Rameshwaram. En route, he meets a woman hailing from a unique family down South. As they find love through this journey in the exuberant lands of South India, an unanticipated drive awaits them.

Tanhaji, a Maratha warrior, is Shivaji Maharaj’s trusted lieutenant. When the Mughals invade and conquer Kondhana fort, he sets out to reclaim it for his king and country.