After being cheated by Narayanan, a house agent, Ajay and Anjali end up sharing the same apartment. Love blossoms between the two while they attempt to catch Narayanan.

For Kumaran (Jayam Ravi), life is about his mother Mahalakshmi (Nadhiya), who was separated from her husband Eeshwar (Prakash Raj). Eeshwar goes on to pursue his passion in kickboxing and becomes a world-renowned trainer based in Malaysia. Mahalakshmi stays in India and devotes her life to bringing up her son. Kumaran is also passionate about kickboxing and shares a special relationship with his mother. In between, he falls in love with Malabar aka Mythili (Asin Thottumkal), but his life is destroyed after his mother’s death. On her deathbed, she tells him to meet Eeshwar, and Kumaran goes to Malaysia to meet him. Kumaran gets a job at his father’s kickboxing academy but finds him with another wife (Aishwarya) and a daughter. Kumaran feels betrayed and angry, and this causes plenty of friction between him and his father. Eeshwar trains a boxer Anand (Subbaraju), whom he is sure will win the championship. Anand is Eeshwar’s devotion, and on many occasions, he demonstrates his preference for Anand over Kumaran. Anand makes Eeshwar’s daughter pregnant and dumps her. He turns traitor to Eeshwar and joins another team when they offer him a better contract.

Surya (Ajith) has been brought up in the army training barracks in Wellington (Ooty), ever since his mother(Sukanya) handed him over as a baby to the camp brigadier (Nasser). She tells the officer the reason for her action but the audience is not allowed to hear it at this point. Surya grows up to be a patriotic youth and the best soldier in his class. He is about to complete his training in 3 months and leave to the border. He falls in love with Indu (Simran), the daughter of a senior army officer, who is visiting Wellington Camp. Indu’s parents accept her choice of husband and the family leaves to kashmir. Soon after, Indu’s father dies in a bomb blast while her mother loses her life on seeing her husband’s body. Not wishing to lose her husband too in war, Indu asks Surya to choose between her and the army. Surya then asks the brigadier to advise him, and the brigadier tells the story of his parents. His father Bomb Sekhar (R. Parthipen) was a very violent terrorist, who was sentenced to 3 years prison and death. His mother was a nun, who visited prisoners and chanted Bible verses to them.

Gokulan sees an attractive girl in his dream and is determined to find her. However, his father gets him engaged to another girl. Complications arise when he meets the woman of his dream soon after.

While attending a wedding, a gregarious young man falls in love with a stubborn woman.

The underworld don Billa (Ajith Kumar), featured on Interpol’s criminal list, is hiding and operating out of Malaysia. DSP Jayaprakash (Prabhu) has spent the last few years looking for Billa, leaving behind a life in India.
During a chase with the police, Billa is severely wounded after an accident and dies in front of the DSP. The DSP then secretly holds a burial of Billa. Interpol officer Gokulnath (Rahman) is assigned to work with DSP Jayaprakash to capture elusive Billa as no-one knows of Billa’s death. DSP Jayaprakash keeps the death of Billa as a secret even from his fellow officers, and tracks down a look-alike called Saravana Velu (Ajith Kumar), a lowly pick-pocket. He asks Velu to infiltrate Billa’s gang by pretending to be Billa. In return he will make sure that the child Velu adopted, Karan, gets a proper education.

Ganesh is obsessively in love with Sandhya, but she is not interested in him. His relentless pursuit leads to a lot of problems. However, everything changes the day he loses his father in an accident.

Jagan (R. Madhavan) and Jamuna (Amogha) meet in a shopping mall in Chennai. They like each other and spend a day chatting in the coffee shop. Jamuna, a believer in destiny, writes down her address and phone number on a Rs.100 note and makes the payment at the cafe declaring that if the note comes back to Jagan, then it means that he was destined to meet her. He tries hard to trace the note, but in vain. Jamuna goes back to Kolkata. Meanwhile, Seema (Pooja), who was rescued by Madhavan from some thugs, has a crush on him. Jagan, unable to find Jamuna, agrees to marry Seema. Finally, Jagan manages to get Jamuna’s address on the eve of her wedding and unites with her.

The film begins with a shot of the Kargil War showing the advances made by Indian soldiers. An Indian Air Force fighter jet is shot down by the enemy. The pilot Varun Chakrapani aka VC (Karthi) ejects from the hit aircraft and lands in enemy territory. The Pakistani Army promptly surrounds him. They imprison him in the Rawalpindi as a Prisoner of War (PoW) and subject him to torture. While being held captive, he reminisces about his romance with Leela (Aditi Rao Hydari).
Leela comes to Srinagar to work as a doctor. Meanwhile, VC has an accident while on a joy ride. He is brought in a critical condition to the hospital. With the duty doctor not available, Leela takes charge, treats VC and nurses him back to health. But, with little regard to her feelings, he gets out of the hospital without her knowledge. Dr. Illyas Hussain (RJ Balaji), an army doctor helps him with this .

Sridhar (Tarun) is a final year degree student and gets selected in the campus selections for studies abroad. He goes to Mumbai for an interview and in his return finds Preeti (Trisha) and loses his heart to her. Sridhar comes to know that Preeti was about to join in degree and Preeti learns that he was a final year degree student. Sridhar is an ardent cricket fan, so is Preeti, while Sridhar is also a good football player. The principal of the college appoints a coach called Reshma (Shriya), who is also a student, for the football team led by Sridhar. Sridhar tries his best to trace Preeti by visiting several women’s colleges, while Preeti also watches for Sridhar at the men’s college. Accidentally, Preeti helps Sridhar’s mother, when she had a heart attack. In order to find Preeti at any cost, Sridhar goes to the LB Stadium, where a cricket match is in progress and gets injuries in a bomb blast in the stadium. Just before the blast, both Preeti and Sridhar find each other but could not meet due to the blast.

A love story that weathers time and emotions. Aditya sees Varsha and it is love at first sight for him. What transpires over the next 7 years is what makes their love stronger.

Uyire Uyire is the Tamil remake of the Nithin and Nithya Menen Telugu starrer – Ishq.