Satyam begins with Sathyam (Vishal), an assistant police commissioner rescuing a hooligan from encounter thirsty cops, only to arrest him later. He reminds his fellow cops that a cop’s duty is to kill crime not criminals. Sathyam meets his first challenge in tracking a mysterious killer of three ministers. In the process, he finds the culprit Manickvel (Upendra), only to receive a rude shock to know his identity.
For, the murderer is none other than a former police officer, who inspired Sathyam to take the cop job. Revealing the reason behind his change of mind, the ex-cop says that he is on a killing spree as he failed to set right things in khakhi uniform.

The film is a sequel to the Tamil comedy – Manal Kayiru which was released in 1982.

The film opens two years after the events of the first film, with Anitha Constructions Civil Engineer, Raghuvaran (Dhanush) winning the Civil Engineer of the Year 2016 Award and is an executive member of his company now, along with a parking spot. His wife, Dr. Shalini (Amala Paul) becomes an authoritative, nagging wife, who controls him. She has resigned her job to take care of the household, after marriage. Raghuvaran is also dismissive about his wife getting another job. Raghuvaran efficiently completes construction projects assigned to him, with the help of about 200 unemployed young Civil, Mechanical and Electrical engineers, who are his friends. Vasundhara (Kajol), a chairman of a big construction company in South India, Vasundhara Constructions, witness the announcement of Raghuvaran’s victory at the Engineer of the Year 2016 Awards and finds out about him. She makes Raghuvaran a job offer, but he humbly refuses, having been interested in creating his own construction company, VIP Constructions.

Rangarajan (Parthiepan) is a physically challenged cab driver and he is also involved in real estate business to earn that extra money for his family. Since Rangarajan can converse in English, his manager (Singampuli) sends him to receive foreign clients and on one such incident, he meets an NRI named Kevin (Shanthanu). Rangarajan helps Kevin who wants a “homely atmosphere” to hire a private bungalow and gets his beautiful young wife Mohini (Parvathy Nair) to cook and do the housekeeping. During his brief stay in India, Kevin understands that Rangarajan is an alcoholic and the young Mohini is not in any way “satisfied with the old man”. This creates confusion in the mind of Kevin who falls for her and is led up the garden path.

Saravanan, who has suicidal tendencies, becomes part of Annachi’s household as the latter, who has a fear of ghosts, believes that he will help him get rid of it.

A happy-go-lucky man accidentally falls in love with a woman whose father despises him. To further complicate matters, his lover has another suitor, who is deemed more worthy of her.

We get a childhood rivalry between Deva (Dinesh uncomfortable) and Villangam (Ramdoss, underutilised), a hastily built romance between Deva and Thulasi (Adhiti Menon), a back story for why Thulasi’s mother (Devayani, with a lousy hair-do) wants a son-in-law who can drive, a henpecked husband (Anandaraj, who takes on the responsibility of making us laugh), a comic character (Rajendran, in an underwritten role) who could expose the hero’s lies…

Vishnu (Nakul) is on his way from Coimbatore for his new job and also to see his Fiance who is his uncle’s daughter. During his journey he meets Pavitra (Nikesha Patel) and upon his arrival in Chennai, problems begin. Simultaneously Narathan (Premji) a renowned movie director is at his uncle’s place who is also a movie producer. Narathan narrates his story to Vishnu’s uncle and interestingly all the incidents have been happening in Vishnu’s and all the other people’s lives.

Sathyamurthy (Vimal) is the son of a schoolteacher DK (Jayaprakash) in Kumbakonam. Sathya is a happy-go-lucky youngster who yearns to do business. To achieve his ‘mission’, he borrows money from all quarters and is almost drowned in debts. Even as his father advises him to start leading life in a right manner, enters Selvi (Sanusha), a student. Sathya gets acquainted to Selvi, and his life takes a turn. Meanwhile, Selvi is in trouble because her uncle Pandiyan (Sarvajit), a rowdy, wants her to marry him. This proposal was ignored by Selvi, and she hated Pandiyan because he killed her father (Santhana Bharathi). One day while goofing around with Sathya, Selvi loses the necklace Pandiyan had given her. Sathya and Selvi escape to Chennai, but Pandiyan and a corrupt inspector come and trouble them. Sathya switches on the police’s cordless phone, through which an Assistant Commissioner of Police (Sampath Raj) comes to know about Pandiyan and arrests him. The film ends with Sathya opening a cable TV station and becoming successful.

Foul-mouthed mutant mercenary Wade Wilson (a.k.a. Deadpool), brings together a team of fellow mutant rogues to protect a young boy with supernatural abilities from the brutal, time-traveling cyborg Cable.

Rajalakshmi is a multi-millionaire who is very proud of her wealth. Her son falls in love with Govindaswamy’s daughter. He is Rajalakshmi’s rival, and hence she always tries to humiliate him in front of everyone.

A group of youngsters takes it upon themselves to bridge the gap between the rich and poor. They uphold the issue of slum dwellers which involves collecting a large sum of money. Will they succeed?