Kadhal Mudichu is a tribute to yesteryear actresses now forgotten by the media and the masses. In the film Akbar Ahmed (Prithviraj) is a highly successful director who wants base his next film on the life of yesteryear actress Malavika (Priyamani). While tracing her whereabouts he finds her diaries which show her whirlwind romance, marriage and consequent break up and its affect on her career. Akbars effors to find Malavika form the plot of the film.
Radharavi is a very rich businessman and has industry with lot of workers. Radharavi bribes the workers union leader Ponambalam if any protest rises from the workers union. Ponambalam cheats the workers by telling the workers that the salary will increase by 5%, but they don’t give up till 7% increase and again the workers stand on the ground protesting. Meanwhile, Ponambalam goes inside alone and gets brandy from Radharavi and again comes out telling now at least 6% increase in salary is agreed by Radharavi and thus tries to settle the protest. Here Sharat Kumar interferes and says that 20% increase is needed. For this whole worker union support Sharat Kumar and make him the leader. Sharat Kumar has a sister who is a close friend to Meena, the daughter of Radharavi. Meena loves Sharat Kumar seeing his good character. Radharavi is very angry with Sharat Kumar already, but tries to change him to be friendly and be like Ponambalam. Radharavi invites Sharat Kumar to the party as Sharat is the new union leader. At the party, Sharat is given a big car and already was given a good clothes to wear for the party. Sharat likes the car and takes the car key and drives the car and damages the car. Sharat also throws away the clothes and says that he prefers to be a poor man till others are given the same offer and comes out of the party. Radharavi has a son who finished studies and come to support him in business. The son of Radharavi falls in love with Sharat Kumar’s sister.
Satya and Deepthi are lovers living in Visakhapatnam. A dreaded don, Veeru Bhai, lusts for Deepthi. When Deepthi’s parents are killed, she and Satya escape. They board a bus on route to Hyderabad, but the bus is stopped unexpectedly and boarded by three men: Veeru’s henchman Deva, Veeru’s brother Ajay, and a corrupt police inspector, Shravan. They kill Deepthi in front of Satya, and he suffers an almost-fatal stab wound. Before the three leave, they set fire to the bus, leaving Satya to his death after stabbing him. However, Dr. Shailaja saves Satya by giving him a new face and skin. Ten months later, Satya wakes up from his coma.
The movie begins in a hospital where a mafia is involved in adulterating drugs. Unfortunately, a junior doctor Alamu (Meenakshi) manages to stumble upon their antisocial act. To safeguard themselves, the gang sets out to wipe out Alamu. She meets Perumal (Sundar C), a petty thief who does the job of recovering loans for an agency. He eventually vows to protect Alamu from her distress by putting an end to the gang and their atrocities.
Raj (Ram Charan) is a Hyderabad-based gambler living with his adopted parents who support his means of living. Tragedy strikes the family when his adopted father (M. S. Narayana) is diagnosed with cirrhosis as a result of alcoholism. Raj needs ₹2 million for his father’s liver transplantation, which must be done within a month. As he is on the lookout for money, he is approached by James (Ajmal Ameer), his rival in betting, with a betting challenge. James dares Raj to make Chaitra (Tamannaah), a dental student and the daughter of a dreaded and influential businessman Bellary (Mukesh Rishi), fall in love with him. If he is able to complete the task before 31 December 2011, James will give him the money needed for his father’s operation; if not, he has to give up betting forever.